{"id":5224,"date":"2023-05-19T20:11:05","date_gmt":"2023-05-19T20:11:05","guid":{"rendered":"https:\/\/reviewofpresbyopia.com\/?p=5224"},"modified":"2023-07-20T16:07:26","modified_gmt":"2023-07-20T16:07:26","slug":"bl-and-novaliq-announce-fda-approval-of-miebo-for-dry-eye-disease","status":"publish","type":"post","link":"https:\/\/reviewofpresbyopia.com\/bl-and-novaliq-announce-fda-approval-of-miebo-for-dry-eye-disease\/","title":{"rendered":"B+L and Novaliq Announce FDA Approval of Miebo for Dry Eye Disease"},"content":{"rendered":"

May 18, 2023<\/strong><\/p>\n

VAUGHAN, Ontario, and HEIDELBERG, Germany \u2014 Bausch + Lomb Corporation and Novaliq GmbH announced that the U.S. Food and Drug Administration (FDA) has approved Miebo, (perfluorohexyloctane ophthalmic solution) formerly known as NOV03, for the treatment of the signs and symptoms of dry eye disease (DED). Miebo is the first and only FDA-approved treatment for dry eye disease that directly targets tear evaporation.<\/p>\n

\u201cToday\u2019s FDA approval of Miebo further advances DED treatment by addressing a significant unmet need for millions of people suffering with this disease,\u201d said Brent Saunders, chairman and CEO, Bausch + Lomb. \u201cWe are proud to bring to market the first and only prescription eye drop approved in\u00a0the United States\u00a0for the treatment of DED that directly targets evaporation. We expect to make Miebo commercially available in the second half of this year.\u201d<\/p>\n

DED affects millions of Americans and is one of the most common ocular surface disorders.1<\/sup> A leading cause of DED is excessive tear evaporation, which due to an altered tear lipid layer, is often associated with the clinical signs of meibomian gland dysfunction (MGD). An unstable tear film triggers increased ocular surface desiccation, inflammation, and damage to the ocular surface.2,3<\/sup>\u00a0Miebo is designed to reduce tear evaporation at the ocular surface.4,5<\/sup><\/p>\n

In GOBI and MOJAVE, two phase three pivotal clinical trials which enrolled more than 1,200 patients (randomized 1:1 to Miebo or hypotonic saline) with a history of DED and clinical signs of MGD, Miebo consistently met its primary clinical sign and patient-reported symptom endpoint.<\/p>\n

“In the two pivotal clinical trials, Miebo addressed the persistent and chronic nature of DED by providing sustained improvement in both the signs and symptoms of DED,\u201d said Preeya Gupta, MD, cornea and cataract surgeon, Triangle Eye Consultants, Raleigh, N.C. \u201cBecause Miebo inhibits evaporation, it may be an appropriate treatment option for patients whose tear evaporation exceeds tear supply.\u201d<\/p>\n

\u201cTear evaporation, which is a leading driver of DED, presents a significant treatment challenge. With the approval of Miebo, eye care professionals can now take a new approach to DED therapy with a first-in-class water- and preservative-free prescription treatment option that specifically addresses tear evaporation,\u201d said Paul Karpecki, OD, director, Cornea and External Disease, Kentucky Eye Institute, and associate professor, University of\u00a0Pikeville, Kentucky\u00a0College of Optometry.<\/p>\n

Clinical Data
\n<\/strong>The FDA approval of Miebo\u00a0was based on results from two 57-day, multi-center, randomized, double-masked, saline-controlled studies, GOBI and MOJAVE, which enrolled a total of 1,217 patients with a history of DED and clinical signs of MGD,6,7<\/sup>\u00a0a major cause of development and disease progression.8<\/sup>\u00a0An estimated 86% of people with DED have excessive tear evaporation whereby MGD is the major contributor.9,10<\/sup><\/p>\n

In the GOBI and MOJAVE phase three pivotal studies, Miebo met both primary sign and symptom efficacy endpoints. The two primary endpoints were change from baseline at week eight (day 57 \u00b1 2) in total corneal fluorescein staining (tCFS) and eye dryness Visual Analog Scale (VAS) score. Patients experienced relief of symptoms as early as day 15 and through day 57 with statistically significant reduction in VAS eye dryness score favoring Miebo observed in both studies. Additionally, at days 15 and day 57, a significant reduction in tCFS favoring Miebo was observed in both studies.<\/p>\n

The most common adverse reactions experienced with Miebo were blurred vision (1.3-3%) and eye redness (1-3%).<\/p>\n

References<\/span><\/p>\n

1 National Eye Institute. Dry Eye<\/a><\/strong>. Last updated April 8, 2022. Accessed May 2, 2023.\u00a0\u00a0<\/span><\/p>\n

2 Craig JP, Nelson JD, Azar DT, et al. TFOS DEWS II report executive summary<\/a><\/strong>.\u00a0Ocul Surf. 2017;15(4):802-812. doi:10.1016\/j.jtos.2017.08.003<\/span><\/p>\n

3 Pflugfelder SC, Paiva CS. The pathophysiology of dry eye disease: what we know and future directions for research.\u00a0<\/a><\/strong>Ophthalmology. 2017;124(suppl 11):S4-S13. doi:10.1016\/j.ophtha.2017.07.010<\/span><\/p>\n

4 Sheppard JD Nichols KK. Dry Eye Disease Associated with Meibomian Gland Dysfunction: Focus on Tear Film Characteristics and the Therapeutic Landscape<\/a><\/strong>. Ophthalmol Ther Published online ahead of print, Mar 1, 2023.\u00a0\u00a0<\/span><\/p>\n

5 Borchman D, Vittitow J, Ewurum A, Veligandl SR. Spectroscopic study of perfluorohexyloctane human Meibum interactions.<\/a><\/strong>\u00a0Invest Ophthalmol Vis Sci.\u00a02022;63:1525.<\/span><\/p>\n

6 Tauber J, Berdy GJ, Wirta DL, et al. NOV03 for dry eye disease associated with meibomian gland dysfunction: Results of the Randomized Phase 3 GOBI Study<\/a><\/strong>.\u00a0Ophthalmology. 2023;130(5):516-524. doi:10.1016\/j.ophtha.2022.12.021<\/span><\/p>\n

7 Sheppard J, Kurata F, Epitropoulos AT, et al. NOV03 for signs and symptoms of dry eye disease associated with meibomian gland dysfunction: The randomized phase 3 Mojave study<\/a><\/strong>.\u00a0American Journal of Ophthalmology. Published online ahead of print. March 20 2023. doi:10.1016\/j.ajo.2023.03.008<\/span><\/p>\n

8 Chhadva P, Goldhardt R, Galor A. Meibomian Gland Disease: The Role of Gland Dysfunction in Dry Eye Disease<\/a><\/strong>.\u00a0Ophthalmology.\u00a02017;124(11S):S20-S26. doi:10.1016\/j.ophtha.2017.05.031<\/span><\/p>\n

9 Findlay, Q., & Reid, K. (2018). Dry eye disease: when to treat and when to refer<\/a><\/strong>. Australian prescriber, 41(5), 160-163.\u00a0\u00a0<\/span><\/p>\n

10 Lemp, MA, Crews, LA, Bron AJ. (2012). Distribution of Aqueous-Deficient and Evaporative Dry Eye in a Clinic-Based Patient Cohort: a retrospective study<\/a><\/strong>. Cornea, 31(5), 472-478. 2012;31(5):472-478. doi:10.109\/ICO.0b013e318225415a.<\/span><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

May 18, 2023 VAUGHAN, Ontario, and HEIDELBERG, Germany \u2014 Bausch + Lomb Corporation and Novaliq GmbH announced that the U.S. Food and Drug Administration (FDA) has approved Miebo, (perfluorohexyloctane ophthalmic solution) formerly known as NOV03, …<\/p>\n

B+L and Novaliq Announce FDA Approval of Miebo for Dry Eye Disease<\/span> Read More \u00bb<\/a><\/p>\n","protected":false},"author":21,"featured_media":5228,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":""},"categories":[138],"tags":[255,521,79,167,322,519,397,518,522,520],"ppma_author":[152],"yoast_head":"\nB+L and Novaliq Announce FDA Approval of Miebo for Dry Eye Disease - Review of Presbyopia & the Aging Eye<\/title>\n<meta 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